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Pedro Pascal is currently living his absolute best life; after rising to fame on Game of Thrones and Narcos, he’s now an A-list star of screens big (Fantastic Four) and small (The Mandalorian, The Last of Us). But things weren’t always golden for the affable star, who recently spoke about his long, long road to fame.

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An interesting study published in the Journal of Clinical Investigation unveils a promising solution to combat bacterial infections, particularly those encased in stubborn biofilms, without relying on traditional antibiotics. Led by researchers from the University of Pennsylvania and Stanford University, the study introduces sugar-coated gold nanoparticles as a novel approach to both diagnose and eradicate biofilms that contribute to dental decay and delayed wound healing.

Biofilms, formed by bacteria like Streptococcus mutans and Staphylococcus aureus, pose a significant challenge as they protect microbes from antibiotic treatment and impede tissue recovery. The newly developed nanoparticles, encapsulating gold spheres within larger cage-shaped structures, offer a dual function: efficient photothermal therapy to kill bacteria and photoacoustic imaging for precise visualization of biofilms.

The study utilized near-infrared lasers to heat gold nanoparticles administered to infected teeth and skin wounds, effectively eliminating biofilms. (Image: Hajfathalian, et al.)

The nanoparticles, coated in dextran to attract bacteria, demonstrated remarkable effectiveness in preclinical trials. When applied to infected teeth and wounded skin of rats and mice, the nanoparticles swiftly eliminated biofilms in as little as one minute, surpassing the performance of conventional antimicrobial agents like chlorhexidine and gentamicin.

For Those Allergic to Antibiotics or Facing Resistant Strains of Bacteria

The key advantage of this approach lies in its antibiotic-free nature, offering a crucial alternative for individuals allergic to antibiotics or facing resistant strains of bacteria. Moreover, the rapid and targeted action of photothermal therapy ensures minimal damage to surrounding tissue while effectively eradicating biofilms.

Lead researcher Maryam Hajfathalian highlighted the cost-effectiveness and simplicity of the treatment, emphasizing its potential to revolutionize infection management. Future studies will explore the preventive and therapeutic capabilities of this innovative strategy, aiming to address issues like cavity prevention and accelerated wound healing.

Gold Nanoparticles Promise Antibiotic-Free Bacterial Eradication

, original content from Ubergizmo. Read our Copyrights and terms of use.

It’s shaping up to be a busy spring for Microsoft, which has multiple events lined up over the next few months. Not only is there a work and Copilot-centric event this Thursday and almost certainly an Xbox showcase coming up in early June, but Build is on the horizon. The company’s major developer conference is set to run from May 21 until May 23. However, three days apparently isn’t long enough to cram in everything Microsoft wants to talk about.

The company sent Engadget an invite to a private event taking place on May 20, the day before Build starts. Details are scant, but Microsoft says CEO Satya Nadella will dig into its “AI vision across hardware and software.” There won’t be a livestream of the briefing, but reporters who attend in person will learn the news first and get hands-on demos.

Microsoft having an “AI vision” that spans across hardware and software lines up with recent reports that the company is gearing up to release its first “AI PCs.” This week’s event is expected to include at least the business and commercial-focused versions of the OLED Surface Pro 10 and Surface Laptop 6.

The consumer variants of the systems may not arrive until later this spring, though those are expected to have significant processor upgrades that will deliver “huge performance and efficiency gains,” according to Windows Central. They’re slated to have Intel Core Ultra or Snapdragon X Elite chips with next-gen neural processing units.

These chips are said to be capable of supporting more advanced AI features that Microsoft plans to bring to Windows later this year, such as on-device Copilot and a tool called AI Explorer. The latter has been described as a searchable timeline of all of your activity on a device.

This article originally appeared on Engadget at https://www.engadget.com/microsoft-is-planning-some-more-pre-build-ai-announcements-194843363.html?src=rss

An interesting study published in the Journal of Clinical Investigation unveils a promising solution to combat bacterial infections, particularly those encased in stubborn biofilms, without relying on traditional antibiotics. Led by researchers from the University of Pennsylvania and Stanford University, the study introduces sugar-coated gold nanoparticles as a novel approach to both diagnose and eradicate biofilms that contribute to dental decay and delayed wound healing.

Biofilms, formed by bacteria like Streptococcus mutans and Staphylococcus aureus, pose a significant challenge as they protect microbes from antibiotic treatment and impede tissue recovery. The newly developed nanoparticles, encapsulating gold spheres within larger cage-shaped structures, offer a dual function: efficient photothermal therapy to kill bacteria and photoacoustic imaging for precise visualization of biofilms.

The study utilized near-infrared lasers to heat gold nanoparticles administered to infected teeth and skin wounds, effectively eliminating biofilms. (Image: Hajfathalian, et al.)

The nanoparticles, coated in dextran to attract bacteria, demonstrated remarkable effectiveness in preclinical trials. When applied to infected teeth and wounded skin of rats and mice, the nanoparticles swiftly eliminated biofilms in as little as one minute, surpassing the performance of conventional antimicrobial agents like chlorhexidine and gentamicin.

For Those Allergic to Antibiotics or Facing Resistant Strains of Bacteria

The key advantage of this approach lies in its antibiotic-free nature, offering a crucial alternative for individuals allergic to antibiotics or facing resistant strains of bacteria. Moreover, the rapid and targeted action of photothermal therapy ensures minimal damage to surrounding tissue while effectively eradicating biofilms.

Lead researcher Maryam Hajfathalian highlighted the cost-effectiveness and simplicity of the treatment, emphasizing its potential to revolutionize infection management. Future studies will explore the preventive and therapeutic capabilities of this innovative strategy, aiming to address issues like cavity prevention and accelerated wound healing.

Gold Nanoparticles Promise Antibiotic-Free Bacterial Eradication

, original content from Ubergizmo. Read our Copyrights and terms of use.

An interesting study published in the Journal of Clinical Investigation unveils a promising solution to combat bacterial infections, particularly those encased in stubborn biofilms, without relying on traditional antibiotics. Led by researchers from the University of Pennsylvania and Stanford University, the study introduces sugar-coated gold nanoparticles as a novel approach to both diagnose and eradicate biofilms that contribute to dental decay and delayed wound healing.

Biofilms, formed by bacteria like Streptococcus mutans and Staphylococcus aureus, pose a significant challenge as they protect microbes from antibiotic treatment and impede tissue recovery. The newly developed nanoparticles, encapsulating gold spheres within larger cage-shaped structures, offer a dual function: efficient photothermal therapy to kill bacteria and photoacoustic imaging for precise visualization of biofilms.

The study utilized near-infrared lasers to heat gold nanoparticles administered to infected teeth and skin wounds, effectively eliminating biofilms. (Image: Hajfathalian, et al.)

The nanoparticles, coated in dextran to attract bacteria, demonstrated remarkable effectiveness in preclinical trials. When applied to infected teeth and wounded skin of rats and mice, the nanoparticles swiftly eliminated biofilms in as little as one minute, surpassing the performance of conventional antimicrobial agents like chlorhexidine and gentamicin.

For Those Allergic to Antibiotics or Facing Resistant Strains of Bacteria

The key advantage of this approach lies in its antibiotic-free nature, offering a crucial alternative for individuals allergic to antibiotics or facing resistant strains of bacteria. Moreover, the rapid and targeted action of photothermal therapy ensures minimal damage to surrounding tissue while effectively eradicating biofilms.

Lead researcher Maryam Hajfathalian highlighted the cost-effectiveness and simplicity of the treatment, emphasizing its potential to revolutionize infection management. Future studies will explore the preventive and therapeutic capabilities of this innovative strategy, aiming to address issues like cavity prevention and accelerated wound healing.

Gold Nanoparticles Promise Antibiotic-Free Bacterial Eradication

, original content from Ubergizmo. Read our Copyrights and terms of use.