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Chinese scientists have achieved a significant medical milestone by successfully curing a long-term type 2 diabetes patient using a novel cell therapy. This breakthrough, reported on April 30 in the journal Cell Discovery, represents the world’s first successful use of stem cell-derived islet transplantation for diabetes.

The patient, a 59-year-old who had been managing diabetes for 25 years, received a transplant of pancreatic cells derived from his own stem cells in 2021 at Shanghai Changzheng Hospital. Prior to this, he had experienced a severe decline in pancreatic islet function following a kidney transplant in 2017, necessitating daily insulin injections.

The innovative treatment involved converting the patient’s blood cells into stem cells, which were then transformed into pancreatic islet cells. Within 11 weeks of the transplant, the patient no longer required external insulin, and within a year, he was able to discontinue oral diabetes medication altogether. Follow-up examinations indicated restored pancreatic and normal kidney functions, suggesting the patient had been cured of diabetes.

Diabetes remains a major global health challenge, affecting 422 million people worldwide, with current management primarily relying on insulin injections and other medications. This groundbreaking achievement in China, which comes after more than a decade of research, offers new hope for a potential cure.

Looking ahead, the FDA has approved a similar cell therapy developed by a Chicago-based startup for type 1 diabetes, showing a growing interest in this approach. However, Chinese researchers emphasize the need for further studies to confirm the long-term efficacy and broader applicability of their treatment. This pioneering work opens new avenues for diabetes therapy, potentially transforming the lives of millions affected by this chronic condition.

Scientists Cure Diabetes With Stem Cell Therapy In World First

, original content from Ubergizmo. Read our Copyrights and terms of use.

Bloober Team’s remake of Silent Hill 2 is due to hit PlayStation 5 and PC on October 8, and it’s looking nice and spooky. It’s available to pre-order on the PlayStation Store and Steam.

It’s been less than two years since Konami and Bloober Team announced the Silent Hill 2 remake, though news of its existence leaked a few months beforehand, giving fans plenty of time to catastrophize the situation. Today we got the first gameplay trailer for the remake, showcasing familiar hallways lined with bloody nurses, low-light environments crawling with bugs, and other nasty surprises that have always been lurking in the sleepy town of Silent Hill. With modern visuals, lighting and sensibilities, it all looks eerily beautiful.

The release date trailer dropped during today’s PlayStation State of Play showcase. Right after that, Konami held a separate event just for its numerous Silent Hill projects, including an extended look at the Silent Hill 2 remake.

Bloober Team is the studio behind the Layers of Fear franchise, Observer, Blair Witch and The Medium — all perfectly serviceable psychological horror experiences. Still, there’s a lot to live up to here: Silent Hill 2 is a beloved, classic horror game. It hit the PlayStation 2 in 2001 and, more than 20 years on, plenty of fans are anxious to see how the remake will hold up. Bloober Team has completely rebuilt the game, including full performance capture and swapping a semi-fixed camera for a modern third-person perspective.

Bloober Team co-founder Piotr Babieno told Engadget in June 2023 that the studio shifted its entire game-making ethos for the Silent Hill 2 remake. Instead of leading with mood and set dressing, they made mechanics the foundation of the on-screen terror, using player input to generate disquiet. The Layers of Fear collection that came out last summer marked the end of Bloober Team’s psychological-horror era. As Babieno said last June:

“This year is like closing the era of making psychological horror games. Right now we are going into Bloober Team 3.0, making mass-market horror…. We decided that our next titles should be much more mass-market oriented. We’d like to talk with more people. We’d like to deliver our ideas, with our DNA, not by environment or storytelling, but by action. So all of our future titles will have a lot of gameplay mechanics. They will be much bigger.”

This article originally appeared on Engadget at https://www.engadget.com/silent-hill-2-remake-hits-ps5-and-pc-on-october-8-230731258.html?src=rss

Bloober Team’s remake of Silent Hill 2 is due to hit PlayStation 5 and PC on October 8, and it’s looking nice and spooky. It’s available to pre-order on the PlayStation Store and Steam.

It’s been less than two years since Konami and Bloober Team announced the Silent Hill 2 remake, though news of its existence leaked a few months beforehand, giving fans plenty of time to catastrophize the situation. Today we got the first gameplay trailer for the remake, showcasing familiar hallways lined with bloody nurses, low-light environments crawling with bugs, and other nasty surprises that have always been lurking in the sleepy town of Silent Hill. With modern visuals, lighting and sensibilities, it all looks eerily beautiful.

The release date trailer dropped during today’s PlayStation State of Play showcase. Right after that, Konami held a separate event just for its numerous Silent Hill projects, including an extended look at the Silent Hill 2 remake.

Bloober Team is the studio behind the Layers of Fear franchise, Observer, Blair Witch and The Medium — all perfectly serviceable psychological horror experiences. Still, there’s a lot to live up to here: Silent Hill 2 is a beloved, classic horror game. It hit the PlayStation 2 in 2001 and, more than 20 years on, plenty of fans are anxious to see how the remake will hold up. Bloober Team has completely rebuilt the game, including full performance capture and swapping a semi-fixed camera for a modern third-person perspective.

Bloober Team co-founder Piotr Babieno told Engadget in June 2023 that the studio shifted its entire game-making ethos for the Silent Hill 2 remake. Instead of leading with mood and set dressing, they made mechanics the foundation of the on-screen terror, using player input to generate disquiet. The Layers of Fear collection that came out last summer marked the end of Bloober Team’s psychological-horror era. As Babieno said last June:

“This year is like closing the era of making psychological horror games. Right now we are going into Bloober Team 3.0, making mass-market horror…. We decided that our next titles should be much more mass-market oriented. We’d like to talk with more people. We’d like to deliver our ideas, with our DNA, not by environment or storytelling, but by action. So all of our future titles will have a lot of gameplay mechanics. They will be much bigger.”

This article originally appeared on Engadget at https://www.engadget.com/silent-hill-2-remake-hits-ps5-and-pc-on-october-8-230731258.html?src=rss

The DAY ONE tracker concept addresses the limitations of current health and activity trackers by monitoring a broader range of habits beyond physical activities. Inspired by the common paper clip, this innovative device aims to remind users of their tasks and track their completion automatically.

Unlike traditional trackers that focus solely on physical health metrics, the DAY ONE tracker is designed to monitor habits that can’t typically be tracked by a smartwatch, such as reading, hydrating, or using specific objects.

The device operates by clipping onto objects associated with the habit a user wishes to cultivate. For instance, attaching the tracker to a book, water bottle, or running shoes allows the device to detect and log the usage of these items through a connected app, similar to checking off a task on a list.

The tracker functions through a base accessory linked to a smartphone, where users can assign the tracker to specific habits. When the attached object is used, the tracker logs the activity, providing a visible and tangible reminder of the habit.

Its paper clip design allows it to be affixed to various objects, whether they are thin like paper or thicker items like tablets or yoga mats. This versatility ensures the tracker can be used in diverse contexts, although its bulkiness might pose challenges in tight spaces or risk being dislodged.

DAY ONE stands out by integrating physical activity tracking with habit formation features in a simple and aesthetically pleasing design. While it requires user commitment to attach and use the trackers appropriately, the visible reminder aspect enhances its potential to encourage consistent habit development.

Despite potential design limitations, the concept offers a meaningful extension to the capabilities of current activity trackers, making them more relevant to everyday behaviors beyond exercise.

Paper Clip-Inspired Habit Tracker Aims To Redefine Activity Monitoring

, original content from Ubergizmo. Read our Copyrights and terms of use.

The DAY ONE tracker concept addresses the limitations of current health and activity trackers by monitoring a broader range of habits beyond physical activities. Inspired by the common paper clip, this innovative device aims to remind users of their tasks and track their completion automatically.

Unlike traditional trackers that focus solely on physical health metrics, the DAY ONE tracker is designed to monitor habits that can’t typically be tracked by a smartwatch, such as reading, hydrating, or using specific objects.

The device operates by clipping onto objects associated with the habit a user wishes to cultivate. For instance, attaching the tracker to a book, water bottle, or running shoes allows the device to detect and log the usage of these items through a connected app, similar to checking off a task on a list.

The tracker functions through a base accessory linked to a smartphone, where users can assign the tracker to specific habits. When the attached object is used, the tracker logs the activity, providing a visible and tangible reminder of the habit.

Its paper clip design allows it to be affixed to various objects, whether they are thin like paper or thicker items like tablets or yoga mats. This versatility ensures the tracker can be used in diverse contexts, although its bulkiness might pose challenges in tight spaces or risk being dislodged.

DAY ONE stands out by integrating physical activity tracking with habit formation features in a simple and aesthetically pleasing design. While it requires user commitment to attach and use the trackers appropriately, the visible reminder aspect enhances its potential to encourage consistent habit development.

Despite potential design limitations, the concept offers a meaningful extension to the capabilities of current activity trackers, making them more relevant to everyday behaviors beyond exercise.

Paper Clip-Inspired Habit Tracker Aims To Redefine Activity Monitoring

, original content from Ubergizmo. Read our Copyrights and terms of use.