PharmaJet, a Spring-Loaded, Needle-Free Injector

The PharmaJet is a spring-loaded gun which fires drugs through your skin, direct into the body. Needle-free injection systems aren’t new, but the PharmaJet has some advantages over older designs.

First, there’s that spring inside, cocked by putting the unit into a box and cranking a handle. This avoids the need for gas-canisters which need to be replaced and recycled. Next up is the actual injection head. This is loaded from a vial of medication, just like you’d do with a needle syringe, and then popped into the gun. You push the whole unit hard up against the skin, hit the trigger and a thin jet of delicious medicine is forced through the skin and into the body.

Once done, the tip is tossed away. This single-use design avoids contamination, and because there are no sharp bits, it’s easier and safer to dispose of the used parts.

For the last two weeks I have had to suffer the Lady jamming a needle into a roll of my belly-fat and plunging a syringe anti-coagulant into my body, to keep things flowing in an immobile broken-leg. While she has drawn blood once, and also hit a muscle (God knows how she found a muscle under the carpet of flab), I think I still prefer the needle. Used properly, you feel almost nothing. With the PharmaJet I’d be screwing up my eyes in anticipation of a sting like you get from a rubber-band fired from point-blank range (although apparently the gun doesn’t actually hurt).

The PharmaJet is approved for use in the US, so maybe you’ll start seeing this Star Trek style tech in hospitals soon.

PharmaJet product page [PharmaJet via Oh Gizmo]

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Bluetooth-enabled meds to enter European bloodstreams

One of the great things about miniaturization is that it allows us to swallow things that a few short years ago were just a wonderful dream, from microprocessors to bowel scanners. Now a Swiss pharmaceutical company called Novartis AG is developing the Ingestible Event Marker (IEM), a chip that can be embedded in medication and, upon being activated by the patient’s stomach acid, will send the doctor biometric data that gauges the drug’s effectiveness (including heart rate, body temp, and body movements) via Bluetooth. The plan is to introduce the technology to monitor transplant recipients, although it could be expanded to other uses as well. If bioequivalence tests demonstrate that the device doesn’t alter the effects of the pills, you could see ’em submitted for regulatory approval in Europe in the next 18 months.

Bluetooth-enabled meds to enter European bloodstreams originally appeared on Engadget on Wed, 10 Nov 2010 14:37:00 EDT. Please see our terms for use of feeds.

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Itchy Genitals? There’s an App for That

Got a mysterious, infuriating itch down there? Then pee on your cellphone, wait a moment, and you’ll know whether you just need to take a shower, or a trip to the doctor.

This is the promise of new research in England, where £4-million ($6.5m) has been given to the UK Clinical Research Collaboration to develop this disposable tech. You don’t have to actually urinate on your phone (unless it is an old pre-Android Motorola handset, in which case you might want to anyway). Instead, you will put a few drops of urine or saliva onto a computer chip which you will then plug into the phone. This laboratory-on-a-chip then chugs into action, analyzing the sample and giving a diagnosis within a few minutes.

The actual details of the chips are still undisclosed, but they will be cheap. The idea is to sell them in vending machines in the same places you would buy condoms, for prices as low as 50p to £1 (80-cents to $1.60), making self-testing into an easy and discreet affair, encouraging those who would normally avoid doctors to check themselves out. The chips would be “about the size of a USB chip,” according to the Guardian, and plug straight into the phone or PC. This makes it likely that it would hook-up via micro-USB, something compatible with pretty much everything except the iPhone.

According to the project chief, Dr Tariq Sadiq, “Britain is one of the worst [countries] in western Europe for teenage pregnancy and STIs (sexually transmitted infections).” As a Brit myself, I can confirm this: When not taking drugs or roaming the dismal streets looking for people to stab, young Britons like nothing more than drunken, dangerous sex. Targeting the tech-savvy, cellphone-loving generation with these tests seems a very smart thing to do.

Mobile phone kits to diagnose STDs [Guardian]

Photo: Ron’s Log/Flickr


Shocker! Laptops placed on laps will overheat you where you don’t want to be overheated

Scrotal hyperthermia — even its name sounds like a terrible, horrible thing. Yes, gadget enthusiasts, we’re talking about the vastly underrated problem that is the overheating of a techie gentleman’s reproductive parts. A study recently published in the Fertility and Sterility journal confirms what we’ve long known — that heat escaping laptops sat on laps can and will raise the temperature in your external offspring storage units — but adds a bit of handy additional info as well. Firstly, it turns out that keeping one’s legs together to balance the laptop is mostly to blame, as it doesn’t provide enough airflow to let heat escape, while lap pads have been found to be entirely ineffective in protecting testicles from rising in temperature. Another note of import is that the men in this study failed to notice when their scrotal thermometers rose above what’s considered safe, so we’d just advise doing your mobile blogging Engadget style: from a bar, a coffee table, the trunk of a car, or even a humble desk.

Shocker! Laptops placed on laps will overheat you where you don’t want to be overheated originally appeared on Engadget on Mon, 08 Nov 2010 15:43:00 EDT. Please see our terms for use of feeds.

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Researchers tout progress with ‘skin printers,’ hope to one day treat battlefield wounds

We’ve already seen that living tissue can be printed using what amounts to a bio-inkjet printer, and some researchers from the Wake Forest Institute for Regenerative Medicine now say they’ve made some considerable progress that could bring the technology one step closer to use on the battlefield. Specifically, they’ve been able to speed up the healing of wounds on mice using a “printed” swath of tissue and completely heal the wound in three weeks, whereas an untreated wound did not heal itself in the same time period. Of course, there’s no word on any plans for tests on humans just yet, but the researchers do plan to take one more step in that direction by moving on to tests on pigs next.

Researchers tout progress with ‘skin printers,’ hope to one day treat battlefield wounds originally appeared on Engadget on Tue, 02 Nov 2010 17:26:00 EDT. Please see our terms for use of feeds.

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UCLA / Caltech researchers help patients move mouse cursors with their brains

It’s certainly not a revolutionary new concept — whiz kids have been tinkering with brain-controlled interfaces for years on end — but a collaboration between UCLA scientists and colleagues from the California Institute of Technology has taken the idea one leap closer to commercialization. Itzhak Fried, a professor of neurosurgery at UCLA, kept a close watch (via embedded electrodes) on how a dozen humans reacted to certain images, and eventually, Fried and co. were able to show that Earthlings can “regulate the activity of their neurons to intentionally alter the outcome of stimulation.” In other words, they were able to move a mouse cursor with just their mind, and brighten a test image with a 70 percent success rate. By honing the process of controlling what actions occur when focused on a given subject (or input peripheral), it opens up the possibility for paralyzed individuals to not only check their email, but also control prosthetic limbs. It’s hard to say when this stuff will be put to good use outside of a hospital, but the video after the break definitely makes us long for “sooner” rather than “later.”

Continue reading UCLA / Caltech researchers help patients move mouse cursors with their brains

UCLA / Caltech researchers help patients move mouse cursors with their brains originally appeared on Engadget on Tue, 02 Nov 2010 04:12:00 EDT. Please see our terms for use of feeds.

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Medtronic debuts tiny lead-less pacemaker at TEDMED 2010

There are two pacemakers in the picture above. There’s the typical clunky, stone shaped device with wires on the right — and on the left, a device dwarfed even by a one-cent coin. This is the Medtronic wireless pacemaker, just revealed at TEDMED 2010, which can be implanted directly into your heart via catheter and permanently latch itself into flesh with tiny claws. Then, doctors can wirelessly monitor and even control the device from a nearby smartphone. Medtronic’s working to make it even smaller still, and we’re hoping to get more information soon. Welcome to the future, folks.

Medtronic debuts tiny lead-less pacemaker at TEDMED 2010 originally appeared on Engadget on Thu, 28 Oct 2010 21:04:00 EDT. Please see our terms for use of feeds.

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NC State gurus find ‘Goldilocks’ of DNA self-assembly, look to improve drug-delivery vehicles

We’re guessing that most Wolfpackers in the greater Raleigh area are in full-on tailgate mode right now, but aside from laying a beating on the Seminoles this evening, NC State faithful are also trumpeting a new DNA discovery that could one day make it easy to get vital drugs to hard-to-reach places within you. Researchers from the university have purportedly discovered the ‘Goldilocks’ of DNA self-assembly, which holds promise for technologies ranging from drug delivery to molecular sensors. The concept, known as DNA-assisted self-assembly, has been vastly improved by using “computer simulations of DNA strands to identify the optimal length of a DNA strand for self-assembly.” You see, perfection occurs when strands aren’t long enough to intertwine with each other, yet not short enough to simply fold over on each other. We know, it’s a lot to wrap your brain around with half a hot dog shoved in your mouth, but hit the video after the break for a… shall we say, more visual explanation.

Continue reading NC State gurus find ‘Goldilocks’ of DNA self-assembly, look to improve drug-delivery vehicles

NC State gurus find ‘Goldilocks’ of DNA self-assembly, look to improve drug-delivery vehicles originally appeared on Engadget on Thu, 28 Oct 2010 15:35:00 EDT. Please see our terms for use of feeds.

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New Science: You Have Taste Receptors in Your Lungs

lung_faces.gifThe human body is weird. A U.K. man recently underwent surgery to remove a tooth growing in his ear. And who could forget the tale of the newborn baby who had a fully-formed foot growing in its brain!? Crazy, right? But, as it turns out, it’s not just the occasional misplaced tooth or aberrant foot, everybody is a freak. According to a recent discovery: we can taste with our lungs.

Researchers at the Maryland School of Medicine recently published their findings regarding a strange discovery: we all have bitter taste receptors growing in our bronchial tissue. The team came upon the find accidentally while pursuing unrelated research into muscle receptors in the lungs.

The bitter taste receptors are the exact same kind located on the tongue, but with two differences: unlike on the tongue, the lung receptors are not bunched into taste buds, and they don’t seem to communicate directly to the brain.

However, these findings may have very real implications for asthma patients. Bitter taste receptors tend to tighten or constrict muscle tissue around them. These lung receptors may exist for a very practical reason: to prevent bitter-tasting plant based poisons from entering the body. But in asthma patients, these reactors may become stimulated by man-made chemicals that they mistake for naturally-occurring plant toxins.

Just nuts.

Flexible, implantable LEDs look set to start a new body modification craze

LED lights are cool, you’re cool, why not combine the two, right? We doubt that’s quite the reasoning that led to this international research project, but it’s certainly an appealing way to look at it. Our old buddy John Rogers from the University of Illinois at Urbana-Champaign has headed up a research team with participants from the US, China, Korea, and Singapore, who have together produced and demonstrated a new flexible and implantable LED array. Bettering previous efforts at inserting lights under the human skin, this approach allows for stretching and twisting by as much as 75 percent, while the whole substrate is encased in thin silicon rubber making it waterproof. Basically, it’s a green light to subdermal illumination, which could aid such things as monitoring the healing of wounds, activating light-sensitive drug delivery, spectroscopy, and even robotics. By which we’re guessing they mean our robot overlords will be able to color-code us more easily. Yeah, that must be it.

Flexible, implantable LEDs look set to start a new body modification craze originally appeared on Engadget on Mon, 18 Oct 2010 10:53:00 EDT. Please see our terms for use of feeds.

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